Chaochao Yan, Qingfang Li, Xiaran Miao, Yimin Zhao, Yawen Li, Pingxia Wang, Kaige Wang, Honghong Duan, Lei Zhang, Liping Cao

Chiral Adaptive Induction of an Achiral Cucurbit[8]uril‐Based Supramolecular Organic Framework by Dipeptides in Water

  • General Chemistry
  • Catalysis
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AbstractChiral induction by natural biomolecules can reveal the indispensable role of chiral structures in life and can be used to develop the chirality‐sensing biomolecular recognition. Here, we present the synthesis and characterization of an achiral supramolecular organic framework (SOF‐1) constructed from cucurbit[8]uril (CB[8]) and hexaphenylbenzene (HPB) derivative (1) in water. Due to the propeller‐like rotational chiral conformation of HPB units and the specific recognition properties of CB[8], SOF‐1 demonstrates chiral adaptive induction in water when interacting with the N‐terminal Trp‐/Phe‐containing dipeptides including L‐TrpX and L‐PheX (X is an amino acid residue), respectively, exhibiting contrasting circular dichroism (CD) and circularly polarized luminescence (CPL) spectra. Consequently, SOF‐1 has been developed as a supramolecular host and chiroptical sensor capable of recognizing and distinguishing the sequence‐opposite Trp‐/Phe‐containing dipeptide pairs including L‐TrpX/L‐XTrp and L‐PheX/L‐XPhe based on the sequence‐selective CD responses.

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