DOI: 10.1021/acs.orglett.6c04339 ISSN: 1523-7060
Chemoselective Phosphine-Catalyzed Reduction of Activated Carbonyls: Access to β-Hydroxy Ketones, Sulfonyls, Phosphonates, and Their Derivatives
Mathieu Zimmermann, Solène Audor, Arnaud VoituriezAbstract
We report a chemoselective phosphine-catalyzed reduction of activated carbonyls in ethanol. This metal-free method employs a recyclable supported catalyst, delivering high chemoselectivity (60 examples) without requiring metal complexes or borohydrides, thus providing a sustainable and practical alternative for selective carbonyl reductions.