DOI: 10.1039/d6md00244g ISSN: 2632-8682
Chemical tools for BAZ2A/B biology: discovery of dual and BAZ2B-selective PROTAC degraders
Iván Cheng-Sánchez, Katherine A. Gosselé, Leonardo Palaferri, Michael Krummhaar, Eleen Laul, Alessio Ciulli, Cristina NevadoSystematic exploration of attachment vectors, linkers and E3 ligase ligands yields a suite of BAZ2 PROTACs, including dual degrader dBAZ2 to the BAZ2B-selective dBAZ2B, with ternary complex formation driving selectivity.