Characteristics and risk of diabetes in people with rare glucose response curve during an oral glucose tolerance test
Yukako Tatsumi, Yoshihiro Miyamoto, Kei Asayama, Michihiro Satoh, Naomi Miyamatsu, Yuko Ohno, Hajime Ikei, Takayoshi Ohkubo- Biochemistry (medical)
- Clinical Biochemistry
- Endocrinology
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Abstract
Context
Existing differences in persons with lower 30- or 60-min plasma glucose (PG) levels during 75-g oral glucose tolerance test (OGTT) than fasting PG remain unclear.
Objective
To clarify the characteristics of persons whose PG levels decrease after glucose administration during OGTT and their risk of incidence of diabetes in a Japanese general population.
Method
In this cohort study, a total of 3995 men and 3500 women (mean age 56.7 years) without diabetes were classified into three groups: (1) PG at both 30 and 60 min ≥ fasting PG; (2) PG at 30 min ≥ fasting PG and PG at 60 min < fasting PG; (3) PG at 30 min < fasting PG. The characteristics and the risk of diabetes onset were analyzed using ordered logistic regression and Cox proportional hazard regression, respectively.
Results
Among 7495 participants, numbers of individuals in the group 1, 2 and 3 were 6552, 769, and 174, respectively. The glucose response curve of the group 3 was boat-shaped. The group 3 had the youngest age, lowest percentage of men, and best health condition, followed by the group 2 and 1. Among 3879 participants analyzed prospectively, 434 developed diabetes during the mean follow-up period of 5.8 years. The hazard ratio for diabetes onset in the group 2 was 0.30 with reference to the group 1. No-one in the group 3 developed diabetes.
Conclusion
People with lower 30-min PG than fasting PG tended to be women, young, healthy, and at low risk of diabetes onset.