DOI: 10.4103/ijpvm.ijpvm_112_25 ISSN: 2008-7802

Changes in Reverse Cholesterol Transport Capacity, ABCG1 Gene Expression, and Atherogenic Index Induced by CX-WORX Training in Obese Women

Samira Sabetrasekh, Allahyar Arabmomeni, Jamshid Banaei Boroujeni
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Abstract

Background and Objective:

Reverse cholesterol transport (RCT) capacity and the ABCG1 transporter play an important role in cholesterol metabolism, and their dysfunction can lead to various complications related to obesity. Exercise has been shown to improve this capacity. Therefore, this study aimed to investigate the changes in RCT capacity, ABCG1 gene expression, and the Atherogenic Index of Plasma (AIP) induced by CX-WORX training in obese women.

Methods:

In this quasi-experimental study with a pre-test-post-test design and a control group, 30 obese women with a mean age of 25.47 years and a body mass index (BMI) of 30–35 kg/m² were purposively selected among obese women in Isfahan in 2024 and randomly divided into two groups: CX-WORX ( n = 15) and control ( n = 15). The CX-WORX training protocol was implemented incrementally over 8 weeks, with three sessions per week, each session lasting 40–50 min. Blood sampling was performed to estimate the study variables at two stages: pre-test and post-test. Real-time PCR (Polymerase Chain Reaction) was used to measure gene expression. In addition, analysis of covariance was used to test the significance of the differences in the means of the groups.

Results:

The results of the study showed that in the experimental group, cholesterol efflux capacity and ABCG1 gene expression increased significantly ( P ≤ 0.05). Additionally, a significant decrease in AIP, Castelli I, and Castelli II was observed in the CX-WORX exercise group ( P ≤ 0.05). Furthermore, after 8 weeks of exercise intervention, total cholesterol, triglyceride, and LDL levels decreased, while high-density lipoprotein (HDL) levels increased significantly ( P ≤ 0.05).

Conclusions:

These results demonstrate the beneficial effects of CX- WORX exercises on RCT capacity, reverse cholesterol transporter gene expression, and atherogenic factors in obese women. Therefore, the use of this exercise method is recommended as an appropriate preventive and treatment strategy for obesity and for improving the indicators involved in RCT.

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