Central serous chorioretinopathy associated with topical prostaglandin analogues

We present two cases with glaucoma who presented with blurred vision or metamorphopsia; the common feature was the ongoing medication with prostaglandin analogue latanoprost and neither patient received systemic corticosteroids or reported stress. Fundus image, optical coherence tomography and angiography confirmed presence of subretinal fluid and diagnosis of central serous chorioretinopathy (CSCR). These cases resolved on withdrawing the offending drug latanoprost, and when the drug was reintroduced for better intraocular pressure management, the serous detachment recurred. We analyse these cases for the role of proinflammatory and haemodynamic effects of prostaglandin analogues (PGA) on initiating CSCR. A review of other similar cases reported earlier is included. The key learning point is to consider potential association of this group of drugs with CSCR, when other risk factors have been excluded.