Cellulose-based Hemostatic Materials in Dental Surgery: A Bibliometric Analysis of Global Research Trends

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BSTRACT

Cellulose-based hemostatic materials are increasingly used in dental surgery for effective bleeding control; however, the global research landscape remains insufficiently characterized. This study aimed to perform a comprehensive bibliometric analysis of research on cellulose-based hemostatic materials in dentistry, identifying publication trends, key contributors, and emerging topics. A bibliometric analysis was conducted using data retrieved from PubMed ( n = 316), Scopus ( n = 29), and Web of Science ( n = 8), yielding a total of 353 records. After removal of 20 duplicates, 333 publications were screened. A total of 43 documents met the inclusion criteria and were analyzed using the Bibliometrix R package and Biblioshiny. The dataset comprised 43 publications from 33 sources, involving 240 authors, with an average of 5.91 co-authors per document and an international collaboration rate of 6.98%. The annual scientific production demonstrated an overall increasing trend, with notable peaks in 2023 and 2025. Clinical Oral Investigations was identified as the most productive journal ( n = 5). Bulgaria ( n = 5 citations), Brazil ( n = 4), and Syria ( n = 3) were the most cited countries. The most productive institution was Medical University Plovdiv ( n = 4). Keyword analysis revealed dominant themes such as “humans” ( n = 37), “female” ( n = 17), and “tooth extraction” ( n = 14), indicating a strong clinical focus. Co-authorship analysis demonstrated a fragmented collaboration network with multiple independent clusters. Research on cellulose-based hemostatic materials in dentistry is growing but remains relatively fragmented, with limited collaboration and moderate citation impact. The field shows a clear shift toward clinically oriented and outcome-based research, highlighting the need for more high-quality studies and stronger international collaboration.