Female urethral adenocarcinoma has attracted attention as a rare tumor type based on its differential pathogenesis from its male counterpart. However, to date, our knowledge concerning its immunohistochemical and morphological characteristics remains limited due to the small number of cases studied. In this study, nine consecutive cases of female urethral adenocarcinoma were used for immunohistochemical and morphological characterization of the tumor based on semi-comprehensive immunohistochemical analysis and detailed morphological evaluations. Our immunohistochemical assay revealed two subtypes of female urethral adenocarcinoma with distinctive staining patterns: the CDX2- and PAX8-expressing subtypes. The former stained positive for other intestinal markers (e.g., HNF4α and TFF1) as well (7 of 7 cases); the latter stained negative for these intestinal markers (0 of 2 cases) but stained positive for clear cell carcinoma markers (e.g., Napsin A and HNF1β) (2 of 2 cases). Regarding cytokeratins, the former displayed a CK7- and CK20-positive immunoprofile (7 of 7 cases); the latter exhibited a CK7-positive and CK20-negative immunoprofile (2 of 2 cases). Morphologically, CDX2- and PAX8-expressing subtypes resembled intestinal-type adenocarcinoma and clear cell carcinoma (occurring in gynecological organs), respectively. The semi-comprehensive immunoprofiling data presented in this study can potentially contribute to the correct diagnosis of this rare tumor type. Finally, our study represents an important basis for future investigations aiming to further elucidate the details and origin of female urethral adenocarcinoma, and it can potentially contribute to developing diagnostic and therapeutic strategies for treating this malignancy.

More from our Archive

• DOI: 10.3390/diagnostics13152582 2023

  What Is Machine Learning, Artificial Neural Networks and Deep Learning?—Examples of Practical Applications in Medicine

  Jakub Kufel, Katarzyna Bargieł-Łączek, Szymon Kocot, Maciej Koźlik, Wiktoria Bartnikowska, Michał Janik, Łukasz Czogalik, Piotr Dudek, Mikołaj Magiera, Anna Lis, Iga Paszkiewicz, Zbigniew Nawrat, Maciej Cebula, Katarzyna Gruszczyńska

• DOI: 10.3390/antiox12071444 2023

  A Review on the Involvement of Heat Shock Proteins (Extrinsic Chaperones) in Response to Stress Conditions in Aquatic Organisms

  Sivakamavalli Jeyachandran, Hethesh Chellapandian, Kiyun Park, Ihn-Sil Kwak

• DOI: 10.3390/diagnostics13142465 2023

  A First Computational Frame for Recognizing Heparin-Binding Protein

  Wen Zhu, Shi-Shi Yuan, Jian Li, Cheng-Bing Huang, Hao Lin, Bo Liao

• DOI: 10.1093/clinchem/hvad080 2023

  Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus

  David B Sacks, Mark Arnold, George L Bakris, David E Bruns, Andrea R Horvath, Åke Lernmark, Boyd E Metzger, David M Nathan, M Sue Kirkman

• DOI: 10.1002/biof.1992 2023

  Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency

  Rodrigo Valenzuela, Adam H. Metherel, Giulia Cisbani, Mackenzie E. Smith, Raphaël Chouinard‐Watkins, Brinley J. Klievik, Luis A. Videla, Richard P. Bazinet

• DOI: 10.3390/diagnostics13152562 2023

  Joint Diagnosis of Pneumonia, COVID-19, and Tuberculosis from Chest X-ray Images: A Deep Learning Approach

  Mohammed Salih Ahmed, Atta Rahman, Faris AlGhamdi, Saleh AlDakheel, Hammam Hakami, Ali AlJumah, Zuhair AlIbrahim, Mustafa Youldash, Mohammad Aftab Alam Khan, Mohammed Imran Basheer Ahmed

• DOI: 10.3390/diagnostics13152489 2023

  An Efficient Ensemble Approach for Alzheimer’s Disease Detection Using an Adaptive Synthetic Technique and Deep Learning

  Muhammad Mujahid, Amjad Rehman, Teg Alam, Faten S. Alamri, Suliman Mohamed Fati, Tanzila Saba

• DOI: 10.1210/clinem/dgad421 2023

  The Value of Targeting CXCR4 With 68Ga-Pentixafor PET/CT for Subtyping Primary Aldosteronism

  Yanqing Zheng, Tingting Long, Ning Peng, Mengling Zhen, Qianwen Ye, Zhen Zhang, Yao He, Zhi Chen, Yu Gan, Min Luo, Chun Li, Zehao Liu, Min Guo, Min Wang, Xianghang Luo, Shuo Hu, Longfei Liu, Tiejian Jiang

• DOI: 10.3390/antiox12071464 2023

  Quinones as Neuroprotective Agents

  Ángel Cores, Noelia Carmona-Zafra, José Clerigué, Mercedes Villacampa, J. Carlos Menéndez

• DOI: 10.3390/diagnostics13152595 2023

  The Applications of High-Intensity Focused Ultrasound (HIFU) Ablative Therapy in the Treatment of Primary Breast Cancer: A Systematic Review

  Dania Zulkifli, Hanani Abdul Manan, Noorazrul Yahya, Hamzaini Abdul Hamid