CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

doi:10.1126/science.1198443

DOI: 10.1126/science.1198443 ISSN:

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

Gregory L. Beatty, Elena G. Chiorean, Matthew P. Fishman, Babak Saboury, Ursina R. Teitelbaum, Weijing Sun, Richard D. Huhn, Wenru Song, Dongguang Li, Leslie L. Sharp, Drew A. Torigian, Peter J. O’Dwyer, Robert H. Vonderheide

Multidisciplinary

Show PDF Cite

CD40 immunotherapy shows efficacy in treating pancreatic cancer in mice and humans by eliciting antitumor immunity.

More from our Archive

DOI: 10.1126/science.adh4129 2023
Culturally determined interspecies communication between humans and honeyguides
Claire N. Spottiswoode, Brian M. Wood
DOI: 10.1098/rsos.231775 2023
Behavioural responses of fin whales to military mid-frequency active sonar
Brandon L. Southall, Ann N. Allen, John Calambokidis, Caroline Casey, Stacy L. DeRuiter, Selene Fregosi, Ari S. Friedlaender, Jeremy A. Goldbogen, Catriona M. Harris, Elliott L. Hazen, Valentin Popov, Alison K. Stimpert
DOI: 10.1073/pnas.2310431120 2023
Navigating the new normal: Examining coattendance in a hybrid work environment
Marie-Laure Charpignon, Yuan Yuan, Dehao Zhang, Fereshteh Amini, Longqi Yang, Sonia Jaffe, Siddharth Suri
DOI: 10.1126/sciadv.adh4363 2023
Estimating birthweight reduction attributable to maternal ozone exposure in low- and middle-income countries
Mingkun Tong, Huiyu Xu, Ruohan Wang, Hengyi Liu, Jiajianghui Li, Pengfei Li, Xinghua Qiu, Jicheng Gong, Jing Shang, Tong Zhu, Tao Xue
DOI: 10.1126/sciadv.adj3955 2023
Efficient current-induced spin torques and field-free magnetization switching in a room-temperature van der Waals magnet
Chao Yun, Haoran Guo, Zhongchong Lin, Licong Peng, Zhongyu Liang, Miao Meng, Biao Zhang, Zijing Zhao, Leran Wang, Yifei Ma, Yajing Liu, Weiwei Li, Shuai Ning, Yanglong Hou, Jinbo Yang, Zhaochu Luo
DOI: 10.1126/science.adi1563 2023
Self-enhancing sono-inks enable deep-penetration acoustic volumetric printing
Xiao Kuang, Qiangzhou Rong, Saud Belal, Tri Vu, Alice M. López López, Nanchao Wang, Mehmet Onur Arıcan, Carlos Ezio Garciamendez-Mijares, Maomao Chen, Junjie Yao, Yu Shrike Zhang
DOI: 10.1126/science.adf4272 2023
On-demand entanglement of molecules in a reconfigurable optical tweezer array
Connor M. Holland, Yukai Lu, Lawrence W. Cheuk
DOI: 10.1126/science.adf8999 2023
Dipolar spin-exchange and entanglement between molecules in an optical tweezer array
Yicheng Bao, Scarlett S. Yu, Loïc Anderegg, Eunmi Chae, Wolfgang Ketterle, Kang-Kuen Ni, John M. Doyle
DOI: 10.1126/sciadv.adj1989 2023
Bacterial denitrification drives elevated N ₂ O emissions in arid southern California drylands
Alexander H. Krichels, G. Darrel Jenerette, Hannah Shulman, Stephanie Piper, Aral C. Greene, Holly M. Andrews, Jon Botthoff, James O. Sickman, Emma L. Aronson, Peter M. Homyak
DOI: 10.1098/rsos.230990 2023
Do food distribution and competitor density affect agonistic behaviour within and between clans in a high fission–fusion species?
Hansraj Gautam, T. N. C. Vidya