Catatonia Developed After Intrathecal Baclofen Dose Adjustment

ABSTRACT

Catatonia is a neuropsychiatric disorder characterized by motor, affective, and cognitive‐behavioral signs. Baclofen is a γ‐aminobutyric acid analog that produces muscle relaxation and is used for various conditions associated with spasticity. Complications associated with baclofen use include life‐threatening withdrawal and intoxication symptoms. Catatonia associated with baclofen administration has rarely been reported. Here, we report a case of catatonia associated with baclofen dose adjustment in a 54‐year‐old woman receiving intrathecal baclofen therapy for spastic paraplegia. Her symptoms responded to the diazepam challenge test and subsequently improved with lorazepam treatment. Clinicians should pay attention to the adjustment period and dose of baclofen and keep in mind the possibility of developing psychiatric symptoms, including catatonia.