Cases of Peters Plus-Like Syndrome at a Tertiary Hospital in Eastern India

Abstract

We report two cases of infants with Peters plus-like syndrome. Case 1 is a male infant with corneal opacity in both eyes since birth. Ophthalmologic examination under anesthesia revealed microphthalmos and microcornea in both eyes, with an inferior corneal scar and iridocorneal adhesion, and a nasolacrimal duct obstruction on the right side. Fundus evaluation of both eyes showed a large uveal coloboma with disk involvement; the disk within the coloboma was dysmorphic, with foveal involvement in the left eye. The patient also had a cleft palate. Case 2 is a female infant with unilateral corneal opacity, bilateral optic atrophy, achondroplasia, atrial septal defect, craniosynostosis, and hydrocephalus. A clinical diagnosis of Peters plus-like syndrome was made in both patients. Management consisted of administration of mydriatic, topical antibiotics, and lacrimal sac compressions for duct obstruction for case 1 and topical mydriatic with patching of the better eye in case 2.