DOI: 10.1177/25158163231195769 ISSN:
Case report: Monoclonal antibodies as an alternative treatment for new daily persistent headache
Ernesto M Bancalari, Natalia Hernández, Analia Soria, Osvaldo Bruera- Neurology (clinical)
Background:
New Daily Persistent Headache (NDPH) is a disabling daily headache that causes huge frustration for patients and headache specialists. Elevated TNF-alpha levels, that elevate CGRP levels, on the CSF of NDPH patients has been described as a possible cause of this disease. TNF-alpha inhibitors like doxycycline, venlafaxine, montelukast and lithium have been used in the past to treat NDPH patients, with relatively good success as described from case reports.
Conclusion:
We report three NDPH patients that improved with the administration of Anti CGRP monoclonal antibodies (mAbs), after trying multiple treatments. We propose this class of drugs, as a therapeutic option for NDPH.