Cardiorenal Profiles Across eGFR Categories in CKD and Chronic Heart Failure: An Exploratory Retrospective Study

Chronic kidney disease (CKD) and chronic heart failure (HF) frequently coexist, but renal dysfunction may not relate uniformly to symptom-based, biomarker, and echocardiographic measures. This retrospective single-center study evaluated 75 adults with CKD and pre-existing cardiologist-confirmed chronic HF, classified at baseline as eGFR G3b (n = 14), G4 (n = 48), or G5 (n = 13). NYHA functional class, NT-proBNP, and echocardiographic parameters were compared across eGFR G categories, and exploratory correlations with continuous eGFR were examined. NYHA functional class distribution differed across categories, with NYHA III–IV present in 14.3% of G3b, 20.8% of G4, and 61.5% of G5 patients. NT-proBNP and E/e′ also differed across categories, and eGFR correlated inversely with NT-proBNP (ρ = −0.251, p = 0.030) and E/e′ (ρ = −0.333, p = 0.003). In contrast, eGFR was not significantly correlated with ordinal NYHA class, LVEF, or PASP, while LVEF, PASP, LAVI, LVMI, and LVH did not differ significantly across eGFR categories. Given the small subgroup sizes, marked sex imbalance across eGFR categories, unadjusted analyses, and absence of correction for multiple comparisons, these findings should be considered descriptive and hypothesis-generating. They suggest partially concordant patterns across functional, biomarker, and echocardiographic domains rather than independent effects of renal function and support cautious multidomain interpretation in CKD–HF populations.