Carbodiimide‐Mediated Deacetylative CC Bond Scission Under Metal‐Free Conditions: A Facile Route to N ‐Sulfonyl Amidines
Sauvik Kashyap, Karabi Deka, Prodeep PhukanAn unprecedented deacetylative bond scission has been achieved through a metal‐free approach involving isonitriles, N , N ‐dibromoaryl sulfonamides, and 1,3‐dicarbonyl compounds. In this transformation, the 1,3‐dicarbonyl compounds act as carbon nucleophiles in the presence of a base. An in situ generated carbodiimide intermediate subsequently undergoes CC bond formation with the carbon nucleophile, followed by deacetylative CC bond scission. This versatile one‐pot synthetic protocol provides access to a diverse range of molecular scaffolds, exhibiting a broad substrate scope and excellent functional‐group tolerance under mild reaction conditions.