Caffeine-Induced Changes in Larval Locomotion and Development of Drosophila Melanogaster
Shekhar Tukaram PhadtareCaffeine (1,3,7-trimethylxanthine) is a widely consumed psychoactive compound that affects neural activity, metabolism, and development across species. This study evaluated dose-dependent effects of caffeine on Drosophila melanogaster larvae using control and three caffeine concentrations (0.25, 0.5, and 1.0 g/ml). The parameters assessed included survival, development, locomotion, heart rate, and reproduction. Results showed mild stimulation at a low dose, indicated by increased activity and heart rate, whereas moderate, while high doses caused reduced lifespan, delayed development, decreased fertility, and increased mortality. The present study suggests a biphasic response, where caffeine acts as a neuro-stimulant at low levels but becomes toxic at higher concentrations.