DOI: 10.1039/d6nr00790b ISSN: 2040-3364
Broadly neutralizing antibodies against HIV-1 pseudoviruses elicited by envelope trimer DNA with chimeric design delivered via silica–calcium phosphate nanoparticles
Fan Ding, Yaotian Chang, Weihao Zhao, Xiaopan Liu, Lipeng Xu, Chunjiang Li, Tianxin Zhang, Yuhua Shi, Yaming ShanBased on the U strategy, a chimeric HIV-1 Env trimer DNA plasmid was constructed and delivered using SCP nanoparticles as the carrier. The levels of binding antibodies and neutralizing antibodies induced by this plasmid were detected in guinea pigs.