DOI: 10.1039/d6md00450d ISSN: 2632-8682
Bridging BET bromodomain and immune checkpoint inhibitors through generative bioorganic frameworks for next-generation cancer immunotherapy
Mohamed K. Diab, Asmaa S. A. Yassen, Sherif Ashraf Fahmy, Heba F. Ashour, Mohamed S. NafieGenerative bioorganic frameworks guide BET bromodomain inhibitor discovery and combination with immune checkpoint inhibitor (ICI) blockade, suppressing MYC/PD-L1 signaling and enhancing antitumor immune responses.