DOI: 10.4103/neuroindia.ni_37_21 ISSN: 0028-3886

Brain Regional Energy Metabolism in Patients with Traumatic Brain Injury: A Cerebral Microdialysis Guided Study

Rajeeb K Mishra, Ashish Bindra, Ankur Khandelwal, Devjyoti Sharma, Keshav Goyal, Girija P Rath, Deepak K Gupta
  • Neurology (clinical)
  • Neurology


In traumatic brain injuries (TBI), cerebral microdialysis (CMD)-derived parameters, especially the lactate to pyruvate ratio (LP ratio), have been utilized for cerebral perfusion optimization. The objectives were to identify cerebral ischemia as measured by CMD in TBI patients requiring decompressive craniectomy and to observe the correlation between cerebral perfusion pressure (CPP), intracranial pressure (ICP), and CMD variables in these patients. Our secondary aim was to observe the effect of CPP augmentation on ischemia biomarkers.


After the Institute Ethics Committee approvals, seven adult patients requiring decompressive craniectomy following TBI were enrolled and CMD data were obtained prospectively for 72 h. CPP was augmented by 20% with noradrenaline infusion if LP ratio >40. Correlations were done with bootstrapping (n = 500) to obtain the confidence intervals (CI) due to the small sample size.


One patient had cerebral ischemia (median LP ratio of 265.5 and median pyruvate of 38 μmol/L), while another patient had non-ischemic mitochondrial dysfunction (median LP ratio 40.7 and median pyruvate 278.5). The coefficients of correlation between the LP ratio with CPP and ICP were r = −0.05 (CI = −0.14–0.03) and r = 0.09 (CI = −0.03–0.24), respectively. The coefficient of correlation between cerebral and blood glucose was r = 0.38, (CI − 0.35–0.14). Only two patients needed CPP augmentation, however, postaugmentation cerebral biochemistry did not change appreciably.


CMD can identify cerebral ischemia, however, no correlations were observed between the LP ratio and CPP or ICP. CPP augmentation did not improve cerebral biochemistry. More studies are required to understand and treat cerebral metabolism in TBI.

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