DOI: 10.1177/17534666261501648 ISSN: 1753-4666

BMP2 may be a promising biomarker for COPD

Yiqiong Wen, Lingyu Li, Qiaoli Fu, Qingqing Qian, Min Li, Ting Li, Wei Ma, Yuanyuan Zheng, Shibo Sun
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Background

Despite the substantial disease burden of chronic obstructive pulmonary disease (COPD), convenient and specific biomarkers for COPD remain lacking.

Objectives

To explore plasma bone morphogenetic protein 2 (BMP2) levels in patients with COPD and the diagnostic value of BMP2 for COPD.

Design

A single-center and cross-sectional observational study.

Methods

Ninety-one patients with COPD and 51 healthy subjects were prospectively recruited as the COPD group and control group, respectively. Plasma BMP2 levels of all subjects were detected. Correlations between BMP2 and other clinical indicators were analyzed. Logistic regression analysis was used to identify the risk factors of COPD. The ROC curve was used to evaluate the diagnostic value of BMP2 for COPD.

Results

Plasma BMP2 levels in COPD group were higher than that in control group ( P < 0.001). The COPD group was divided into acute exacerbation of COPD (AECOPD) group (n=59) and stable COPD (SCOPD) group (n=32). Plasma BMP2 levels in the SCOPD group were higher than that in the AECOPD group ( P < 0.001). In addition, plasma BMP2 levels in the control group and COPD group were negatively correlated with PEF, FEF 25 , FEF 50 , FEF 75 , and DLCO ( P < 0.05). Plasma BMP2 in the COPD group were positively correlated with FEV 1 /FVC, FEV 1 %pred, FEF 25 , FEF 50 , and FEF 75 ( P < 0.05). Importantly, logistic regression analysis showed that BMP2 was an independent risk factor for COPD (adjusted OR = 1.115, 95% CI: 1.065–1.166, P < 0.001). Moreover, the AUC of BMP2 in distinguishing COPD group from control group was 0.763 (95% CI: 0.686-0.839, P < 0.001), and that in distinguishing AECOPD group from SCOPD group was 0.722 (95% CI: 0.610-0.834, P < 0.001).

Conclusions

Plasma BMP2 level is elevated in patients with COPD. Moreover, BMP2 is an independent risk factor for COPD and has auxiliary diagnostic value for COPD. Consequently, BMP2 may be a promising biomarker for COPD.

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