DOI: 10.1039/d6sc01721e ISSN: 2041-6520
Bioinspired peptide cyclisation enables exploration of cytochrome P450 catalysed sequential oxidation in rufomycin biosynthesis
Jessica Peate, Yaoyu Ding, Joshua Tomkins, Harry R. Winter, Jingwen Zhang, Cameron M. L. Coleman, Priya Solanki, Jake H. Nicholson, Toby Hopkinson, Gustavo Perez-Ortiz, Alex P. S. Brogan, Timothy D. McHugh, Robert E. Jefferson, Sarah M. BarryChemoenzymatic route to rufomycin analogues reveals fundamental insight into RufM catalysed sequential oxidation and surprising substrate tolerance.