In large datasets, irrelevant, redundant, and noisy attributes are often present. These attributes can have a negative impact on the classification model accuracy. Therefore, feature selection is an effective pre-processing step intended to enhance the classification performance by choosing a small number of relevant or significant features. It is important to note that due to the NP-hard characteristics of feature selection, the search agent can become trapped in the local optima, which is extremely costly in terms of time and complexity. To solve these problems, an efficient and effective global search method is needed. Sand cat swarm optimization (SCSO) is a newly introduced metaheuristic algorithm that solves global optimization algorithms. Nevertheless, the SCSO algorithm is recommended for continuous problems. bSCSO is a binary version of the SCSO algorithm proposed here for the analysis and solution of discrete problems such as wrapper feature selection in biological data. It was evaluated on ten well-known biological datasets to determine the effectiveness of the bSCSO algorithm. Moreover, the proposed algorithm was compared to four recent binary optimization algorithms to determine which algorithm had better efficiency. A number of findings demonstrated the superiority of the proposed approach both in terms of high prediction accuracy and small feature sizes.

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