Bilateral Middle Cerebellar Peduncle Infarctions After Influenza A Infection in a Patient of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

ABSTRACT

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small‐vessel disease (SVD) caused by pathogenic NOTCH3 gene mutation. We report a case in which a patient was diagnosed with CADASIL after presenting with infarctions in the bilateral middle cerebellar peduncles (MCPs) and bilateral cerebral watershed areas following an influenza A virus infection. In this case, border‐zone ischemia may have resulted from impaired cerebral autoregulation caused by the underlying small‐vessel pathology of CADASIL. Influenza A infection may have served as a triggering factor for the ischemic event.