DOI: 10.1039/d6qo00837b ISSN: 2052-4129
Bidirectional synthesis of the C1–C15 fragment of iriomoteolide-13a from the key C5,C6,C8-trisubstituted THF intermediate
Haichen Ma, Wei-Min DaiThe target fragment has been synthesized from the C4–C11 THF core via cross-metathesis/alkene isomerization (at C4) and Kishi ketone synthesis (at C11) from both termini of the carbon chain.