BG13 Impact of polypharmacy on skin integrity in older adults: a narrative review

Abstract

Older adults are particularly vulnerable to skin fragility due to ageing and comorbidities. Polypharmacy, prevalent in this population, may contribute to adverse skin effects, including xerosis, bruising, impaired wound healing and increased susceptibility to drug-induced rashes. Despite its clinical relevance, the interaction between polypharmacy and skin integrity remains underexplored. Understanding these effects is crucial for dermatologists and geriatricians to optimize care and prevent complications. This study is a review of the current literature on the impact of polypharmacy on skin health in older adults, highlighting mechanisms, common drug-related skin adverse effects, and implications for clinical practice. A narrative review of PubMed and Embase studies published between 2015 and 2025 was conducted. Studies were included that focused on adults aged ≥ 65 years taking multiple systemic medications and reporting dermatological adverse effects, skin fragility or delayed wound healing. Outcomes extracted included prevalence, mechanism and management strategies. Polypharmacy is associated with increased risk of xerosis, purpura, delayed wound healing and drug-induced rashes. Common culprit medications include anticoagulants, corticosteroids and psychotropics. Interactions between multiple drugs exacerbate dermatological vulnerability. Preventative strategies include careful medication review, patient education and monitoring of skin integrity during routine care. Polypharmacy significantly impacts skin health in older adults. Awareness and proactive management can mitigate risks and improve patient outcomes. Clinicians should integrate dermatological monitoring into geriatric medication management and consider deprescribing where appropriate.