DOI: 10.1126/scisignal.aeh8955 ISSN: 1945-0877
Beyond the scaffold: Glia as architects of the neural extracellular matrix
John Lenon de Souza Santos, Dolores IralaAstrocytes, oligodendrocyte lineage cells, and microglia dynamically shape the neural extracellular matrix (ECM) across brain development and aging. Recent findings highlight the potential of glial regulation of the ECM as a framework for understanding circuit formation and identify previously unrecognized targets in neurological diseases.