DOI: 10.1139/cjc-2023-0146 ISSN: 0008-4042

Benzotriazepine synthesis, conformational analysis, and biological properties

Sarah-Maude Harvey, Xiaozheng Wei, Darince Truong, William D. Lubell
  • Organic Chemistry
  • General Chemistry
  • Catalysis

Various benzotriazepine ring systems have been synthesized and examined for biological activity. Moreover, the 1,3,4-benzotriazepin-2-one has been shown to act as a constrained amino amide surrogate in mimics of peptide turn secondary structures. This review examines syntheses of the different benzotriazepine ring systems and heterocycle fused variants as well as their conformational and biological properties.

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