Basophilic degranulation: Striking light microscopic visual of peripheral blood smear of a participant with cold urticaria

Basophil is the rarest leukocyte, which releases their granules upon exposure to specific antigens called basophilic degranulation. Usually, this moment is hardly observed under microscope as basophilic granules are water soluble and washed away during the staining process. A stained blood film of a 31-year-old woman is presented to illustrate this event precisely using a micrograph where granules have left the basophil and concentrated around the cell like a “cloud.” The basophil with a distinct tri-lobed nucleus, ruptured cell membrane and dispersing granules without staining artifacts confirmed this event which may serve as a potent tool in education, research, and clinical practices.