Aims: Obesity is a major public health problem that is increasing globally. The ability to predict factors associated with weight loss in the treatment of obesity may contribute to the development of individualized therapeutic approaches. The aim of this study was to investigate parameters related to weight loss response in obese individuals receiving orlistat treatment. Methods: This single-center, retrospective study evaluated the data of 161 patients who were initiated on orlistat therapy due to obesity. Patients were categorized into three groups based on weight loss achieved at 6 months: non-responders (