Batia Weisselberg, Jacob Yahav, Brian Reichman, Anita Jonas

Basal and Meal‐Stimulated Pepsinogen Secretion in Preterm Infants

  • Gastroenterology
  • Pediatrics, Perinatology and Child Health

SummaryIn order to establish longitudinal normal values for basal and meal‐stimulated pepsinogen secretory function in preterm infants, we studied 44 preterm infants with gestational ages of 28–36 weeks during the period of nasogastric tube feeding. Three age groups were evaluated: gestational ages of 28–30, 31–33, and 34–36 weeks. Basal pepsinogen did not change with postnatal age in any of the groups. Significant meal‐stimulated pepsinogen secretion appeared during the third postnatal week in infants of 28–30 weeks of gestation. In the groups of infants of 31–33 and 34–36 weeks of gestation, significant meal‐stimulated pepsinogen secretion was apparent in the first postnatal week. This study suggests that maturation of pepsinogen secretion appears at 31 weeks of gestation, independent of early feeding.

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