Bacterial biosynthetic gene clusters

Abstract

The concept of biosynthetic gene clusters (BGC) has been at the centre of the study of bacterial secondary metabolism during this century, allowing a major transition in how this elusive complex trait was historically investigated, from individual cases to currently focusing on general emerging principles. During the last century, marked by a community of practitioners consisting of chemists and microbiologists mainly using analytical chemistry and microbiological techniques, the field has evolved into a richer and more diverse scientific community using genetic, genomic, chemical, and structural biology and evolutionary and ecological approaches, with broader implications. This transition coincides not only with the emergence and consolidation of the so-called ‘omics’ sciences but also with the terms ’natural products’, mainly used by biological chemists exploring biotechnological applications of secondary metabolites, and ‘specialised metabolites’, embraced by microbiologists aware of the broader ecological and evolutionary dimensions of the metabolites encoded by BGCs.