DOI: 10.1039/d6ob00923a ISSN: 1477-0520
B-ring methoxy substitution modulates flavokawain membrane interactions and cytotoxicity
Paulina Strugała-Danak, Ewa Dejnaka, Paweł Chlipała, Anita Dudek, Hanna Pruchnik, Joanna Sulecka-Zadka, Karolina Motykiewicz-Pers, Aleksandra Pawlak, Bożena Obmińska-Mrukowicz, Tomasz JaneczkoB-ring methoxy topology modulates flavokawain membrane ordering, albumin binding and cytotoxicity, revealing a multi-parameter SAR framework for further optimization of chalcone-based bioactive compounds.