DOI: 10.1152/ajpregu.00144.2026 ISSN: 0363-6119
Autonomic dysregulation and high arterial blood pressure in male Crtc1 -deficient mice
Karoline Morhenn, Fabio Morellini, Anika Seniuk, Helga Vitzthum, Heimo EhmkeMale Crtc1-deficient mice develop autonomic dysfunction and high arterial blood pressure, likely driven by enhanced α 1 -adrenergic vasoconstriction and independent of obesity or increased arteriolar wall thickness. The co-occurrence of elevated sympathetic activity, early cardiac remodeling, impaired glucose tolerance, and depression-related behavior suggests an involvement of CRTC1-dependent signaling in the coordination of autonomic, metabolic, and affective phenotypes.