Autologous Conditioned Serum Improves Early Wound Healing Scores of Postextraction Dental Wound in Dogs

This retrospective study evaluated the potential role of autologous conditioned serum (ACS) as an adjunctive therapy to improve postextraction dental wound healing in dogs. Clinical records of 40 dogs that underwent tooth extraction were included in the analysis. Data from 20 dogs that had received ACS applied to the extraction site following suturing were compared with those from 20 dogs that received the standard treatment. Healing outcomes were assessed from follow-up notes at days 3, 7 and 14, using the Early Wound Healing Score (EHS) to evaluate haemostasis, inflammation, and wound margin closure. Analysis revealed that dogs treated with ACS demonstrated significantly higher EHS compared to controls. By day 3, the ACS group showed a significant improvement in EHS compared to controls ( P  = .01), with a large effect size (Hedges g  = 0.87). The higher clinical scores persisted at day 7, with a significantly higher score for clinical signs of reepithelialization in the ACS group ( P   =  .02, Hedges g   =  0.78). These differences were observed across subgroups, regardless of patient demographics or clinical presentation within the study population. The findings suggest that ACS is associated with improved EHS, including reepithelialization and haemostasis scores.