DOI: 10.3390/md22040171 ISSN: 1660-3397
Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica
Yasumoto Oyadomari, Yasuyuki Goto, Keisuke Suganuma, Shin-ichiro Kawazu, Leontine E. Becking, Nobuhiro Fusetani, Yoichi Nakao- Drug Discovery
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
- Pharmaceutical Science
A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 µM.