DOI: 10.1111/cup.70198 ISSN: 0303-6987
Atypical Lentiginous Melanocytic Proliferations Case Series: Relationship to Type
II
Dysplastic Nevi and Lentiginous Melanoma
Maged Daruish, Ella De Ryck, Laura Gadeyne, Julie Lemahieu, Siebe Loontiens, Joni Van Der Meulen, Marc Haspeslagh, Boris C. Bastian, Saleem Taibjee ABSTRACT
A recent study described a distinctive subset of dysplastic nevi in older patients, genetically characterized by non‐BRAFV600E driver mutations and frequent TERT promoter mutations. It has been proposed that these lesions overlap with the so‐called lentiginous dysplastic nevi of the elderly. We explore this relationship in a series of 24 atypical lentiginous melanocytic proliferations, correlating with ex vivo dermoscopy, as well as immunohistochemical and molecular findings. We also discuss the utility of the MPATH‐Dx tool to improve consensus for such lesions.