Associations of the Baseline Level and Change in Estimated Glucose Disposal Rate With Incident Dementia, Cognitive Functions, and Brain Structure: Findings From the
UK
Biobank Study
Wenyang Han, Yiqun Li, Pinni Yang, Yiming Jia, Lulu Sun, Ruirui Wang, Mengyao Shi, Xiaowei Zheng, Yonghong Zhang, Zhengbao Zhu ABSTRACT
Aims
The aim of this study was to investigate the association of baseline and changes of estimated glucose disposal rate (eGDR) with incident dementia, cognitive functions, and brain structure based on the UK Biobank.
Methods
A total of 440 295 participants, and 12 723 (with two measurements of eGDR) without dementia at baseline (followed until November 2022.) were analyzed.
Results
Higher baseline eGDR level was associated with decreased risk of incident dementia (HR = 0.43, 95% CI: 0.39–0.47). Compared to persistently low level of eGDR (Class 1), those with high level decreasing (Class 3, HR = 0.60, 95% CI: 0.35–0.95) and persistently high level (Class 4, HR = 0.47, 95% CI: 0.28–0.77) of eGDR were associated with decreased risks of dementia. In addition, those with higher baseline and persistently high level of eGDR were associated with favorable cognitive functions, and better brain structure.
Conclusion
A high baseline eGDR level, high level decreasing, and persistently high level in eGDR level are associated with decreased risks of incident dementia.