DOI: 10.4103/mjbl.mjbl_1760_23 ISSN: 1812-156X

Association of the toll-like receptor4 rs41426344G>C polymorphism with rheumatoid arthritis in a group of Iraqi patients

Luma Yaseen Aldouri, Mohammed I. Nader, Mohammed Hadi Munshed Al-Osami
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Abstract

Background:

Rheumatoid arthritis (RA) is an inflammatory joint disorder affecting various joints throughout the body. Toll-like receptors are essential for the immune system’s ability to defend against infections and maintain homeostasis. In particular, TLR-4 has been studied for its role in autoimmune diseases such as RA.

Objectives:

This study explored how molecular variations in TLR-4 might impact the likelihood and susceptibility of Iraqis to develop RA.

Materials and Methods:

The study included 100 participants, 50 of whom had RA, whereas the other 50 did not serve as controls. Genotyping was performed using high-resolution melting techniques through reverse transcription polymerase chain reaction (RT-PCR) to investigate the effects of genetic risk factors associated with the TLR-4 gene between the two groups.

Results:

Significant differences in the frequency of TLR-4 rs41426344 alleles and genotypes were observed between patients with RA and controls. The CC genotype of the TLR-4 gene in the (rs41426344SNP) shows a risk for RA (20% vs. 0% in healthy individuals), the ( χ 2 = 8.77; OR= 26.18(1.48–460.36) and P = 0.0084, respectively, whereas the other genotypes (GG and GC) showed no risk for RA in the studied samples of the Iraqi population.

Conclusion:

This case-control study analyzed, for the first time, the influence of TLR-4 gene polymorphisms on RA pathogenesis in the study population.

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