Association of Adiponectin Levels with Polycystic Ovary Syndrome among Iraqi Women
Yasameen Imad Kadhim, Fadhil Jawad Al-Tu’ma, Nora Sabah RasoulAbstract
Background:
Polycystic ovarian syndrome (PCOS) is a hormonal condition marked by an imbalance in women’s reproductive hormones within the endocrine system. The pathophysiology of PCOS appears to be multifactorial and polygenic. Adiponectin is a protein specific to adipocytes that plays a key role in maintaining lipid and glucose homeostasis. It also has insulin-sensitizing and antidiabetic effects. Adiponectin seems to play an important role in the pathogenesis of PCOS, especially in obese women.
Objectives:
To analyze the serum adiponectin levels in people with PCOS and examine any potential correlations between adiponectin and other variables.
Materials and Methods:
From November 2022 to September 2023, 160 individuals were gathered for a case-control research design. Eighty women were chosen as PCOS patients, and the remaining subjects were enrolled as an apparently healthy control group. The University of Kerbala, the College of Medicine, and the Kerbala Health Directorate gave ethical approval for the study. The management of teaching hospitals that specialize in obstetrics and gynecology also gave their approval. Lipid profile (total cholesterol [TC], triglyceride [TG], high-density lipoprotein-cholesterol [HDL-C], and low-density lipoprotein-cholesterol [LDL-C]), insulin, and glucose were determined. Adiponectin levels in the blood were assessed in both groups using the enzyme-linked immunosorbent assay (ELISA) test.
Results:
When comparing PCOS women to controls, there was a substantial drop in serum adiponectin (
Conclusion:
Significantly lower blood adiponectin levels can be applied to specific new therapy methods where follow-up demonstrates improvement in adiponectin levels, and they can be useful as diagnostic and prognostic measures for women with PCOS.