Association between urine protein‐to‐creatinine ratio and postpartum resistant hypertension in patients with severe preeclampsia: A retrospective cohort study
Walter Annicchiarico, Jorge Hernan Gutiérrez Marin, Raúl Alejandro García Posada, Diana Paola Cuesta Castro, José Enrique Sanín Blair, María Nazareth Campo CampoAbstract
Objective
Our objective was to investigate the association between elevated urine protein‐to‐creatinine ratio (UPCR) and resistant hypertension during postpartum hospitalization in patients with severe preeclampsia at a tertiary care center in Colombia.
Methods
This retrospective cohort study was conducted in Medellín, Colombia. Patients aged >18 years diagnosed with severe preeclampsia who underwent UPCR assessment were included. Associations between elevated UPCR (≥0.3) and resistant hypertension during postpartum hospitalization were evaluated using robust Poisson regression models.
Results
A total of 261 patients were included in the study. Bivariate analysis showed that resistant hypertension in the postpartum period was more frequent in the UPCR ≥0.3 group than in the UPCR <0.3 group (43.2% vs. 12.7%; risk ratio 3.69; 95% confidence interval 1.92–7.07). After adjustment for maternal age, body mass index, and gestational age at diagnosis, elevated UPCR remained independently associated with resistant hypertension (adjusted risk ratio 4.87; 95% confidence interval 1.86–12.76). Earlier gestational age at diagnosis was also independently associated with resistant hypertension.
Conclusion
The UPCR is independently associated with the development of resistant hypertension during postpartum hospitalization in patients with severe preeclampsia.