DOI: 10.1002/ajhb.24059 ISSN: 1042-0533

Association between oxidative balance score and inflammatory markers in middle‐aged and older Japanese people

Hinako Nanri, Megumi Hara, Yuichiro Nishida, Chisato Shimanoe, Yasuki Higaki, Keitaro Tanaka
  • Genetics
  • Anthropology
  • Ecology, Evolution, Behavior and Systematics
  • Anatomy



This study aimed to investigate the association between oxidative balance score (OBS), wherein higher OBSs indicate lower oxidative stress, and high‐sensitivity C‐reactive protein (hs‐CRP), as well as inflammatory scores, in a large cohort of Japanese adults.


In total, 9703 individuals aged 40–69 years participated in a baseline survey of a population‐based cohort study in Saga, Japan (2005–2007). OBSs were calculated from 11 prooxidant and antioxidant lifestyle factors, including dietary intake, physical activity, alcohol consumption, and smoking status. Lifestyle data, including dietary intake, were obtained using a self‐administered questionnaire. Adjusted geometric means of serum hs‐CRP levels were calculated based on OBS quartiles, and linear trend tests were performed, with adjustments for potential confounders. In addition, an inflammatory cytokine z‐score was constructed and assessed alongside individual markers.


After adjusting for multiple confounders in both sexes, the results showed a significant inverse association between OBS and serum hs‐CRP levels in both men and women. These results remained unaltered when the OBS evaluation excluded powerful prooxidants, serum ferritin, or smoking. There was also an association between OBS and lower inflammatory z‐score, indicating reduced overall systemic inflammation.


These findings suggest that a higher OBS, indicating a greater predominance of antioxidants over prooxidant exposure, is associated with lower hs‐CRP levels and reduced systemic inflammation, regardless of sex.

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