DOI: 10.1002/alz.074148 ISSN: 1552-5260

Association between Mild Behavioral Impairment trajectories and AD biomarkers in adults with Mild Cognitive Impairment. Results from the CompAS study

Sabela Carme Mallo, Miguel Ángel Rivas Fernández, Laura Vázquez‐Vázquez, Santiago Galdo‐Álvarez, Mónica Lindín, Ana Nieto‐Vieites, Onésimo Juncos‐Rabadán, Jose M. Aldrey, Fernando Díaz, Zahinoor Ismail, Arturo X Pereiro
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Geriatrics and Gerontology
  • Neurology (clinical)
  • Developmental Neuroscience
  • Health Policy
  • Epidemiology



Our aim was to investigate the association of the NPS trajectories in time measured by MBI‐C for MCI patients with the CSF biomarkers and temporal lobe atrophy detected at baseline.


CSF biomarkers at baseline were obtained from 71 patients with MCI belonging to Compostela Aging Study (CompAS) (Spain). Positivity for A (β‐amyloid), T (p‐Tau), and N (t‐Tau) was defined by cut‐off levels. Structural MRI was employed to evaluate cortical thickness and volume. Mild behavioral impairment was assessed using the validated Spanish‐language MBI‐C (Mallo et al., 2018) at baseline, 24 months, and 60 months follow‐up. Spearman correlations were performed to evaluate the relationships between CSF biomarkers at baseline and MBI‐C scores for the three evaluations. Logistic regressions were used to test the predictive value of the MBI‐C scores at each evaluation on the biomarkers’ positivity at baseline, and linear regression analyses to test the relationships between cortical thickness and volume at baseline and the three MBI‐C scorings.


Spearman correlations showed no significant relations between MBI‐C and β‐amyloid, pTau, tTau and tTau/β‐amyloid ratio at baseline. However, significant positive correlations appeared between MBI‐C at 24‐month follow‐up and pTau (rho = .371), tTau (rho = .282) and tTau/β‐amyloid ratio at baseline but not with β‐amyloid. MBI‐C scores at the 60‐month follow‐up only significantly correlated with tTau/β‐amyloid ratio (rho = ‐.418). MBI‐C at 24 months and at 60 months were respectively predicted by pTau and tTau (Table 1). Linear regression analyses showed that MBI‐C at 24 months was predicted by cortical thickness of entorhinal, fusiform, inferior temporal, inferior parietal, middle and supramarginal gyri. MBI‐C at 24 and 60 months were predicted by Volume of entorhinal, inferior temporal, precuneus and whole hippocampus (Table 2).


The markers of atrophy in structures of the medial temporal lobe and the lateral and parietal temporal lobe, and pTau+ or tTau+ in MCI patients at baseline were associated with worsening of neuropsychiatric symptoms at 24 and/or 60 months.

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