Association between low-dose aspirin use and serum uric acid levels in older adults: a cross-sectional analysis from the baseline survey of the LAPIS study
X Wang, M E I L I N LiuAbstract
Background
Low-dose aspirin is widely used in older adults for cardiovascular prevention, yet its effect on serum uric acid (SUA) metabolism remains uncertain. This study examined the association between low-dose aspirin use and SUA levels among older adults.
Methods
A cross-sectional analysis was conducted using baseline data from 5,902 participants aged ≥60 years in the LAPIS study. Aspirin exposure was categorized as non-use, 50 mg/day, or 100 mg/day. SUA and hyperuricemia (HUA; ≥420 µmol/L) were analyzed using multivariable linear and logistic regression, with adjustments for demographic, clinical, and laboratory variables. Sensitivity and subgroup analyses were performed by renal function, body mass index (BMI), and diuretic use.
Results
Aspirin users had higher median SUA levels than non-users (317.0 vs 304.0 µmol/L, p<0.001), but after full adjustment, aspirin use was not independently associated with SUA or HUA (p for trend >0.05). Results were consistent after excluding diuretic users. A significant interaction with BMI was observed (p for interaction = 0.026), with higher HUA odds among obese participants (BMI ≥ 28 kg/m²; OR = 2.02, 95% CI 1.16–3.61).
Conclusion
Low-dose aspirin (50–100 mg/day) was not independently linked to elevated SUA or HUA risk in older adults, though obesity may amplify the association.Aspirin UA BoxplotFor image description, please refer to the figure legend and surrounding text.Subgroup and interaction analysesFor image description, please refer to the figure legend and surrounding text.