Association between Helicobacter pylori Infection and Risk of Non-Alcoholic Fatty Liver Disease
Amal Shawky Bakir, Hany Ali Hussein, Salah Shaarawy Galal, Mahmoud Mohamed Abdul Azeem Amer- General Medicine
Abstract
Background
Nonalcoholic fatty liver disease (NAFLD) is an epidemic liver disease affecting approximately 25% of the general population. It has a wide range of clinical phenotyping from hepatic steatosis to non- alcoholic steatohepatitis (NASH), advanced fibrosis and liver cirrhosis.
Aim of the Work
To find out the link between H. Pylori infection and the onset of Non-alcoholic fatty liver disease.
Patients and Methods
This cross sectional, case control study was conducted on 80 patients presented with H-Pylori in Ain Shams University Hospitals during the period from September 2020 to June 2021, after taking informed consents from the patients.
Results
Our study shows a statistically significant association between age and NAFLD occurrence. Our study showed that gender has no influence on occurrence of NAFLD. Also, we found that NAFLD is associated with elevated levels of TG, Cholesterol &LDL. Our study showed that high SBP, DBP is associated with increased risk of NAFLD. The levels of AST and ALT in our study were significantly higher in risky group patients than in non-risky group patients. Regarding the degree of fibrosis in patients with NAFLD using NFS we found that risky patients were associated with increased risk of fibrosis.
Conclusion
Our study suggested that H-Pylori infection may have a role in NAFLD occurrence. However, other metabolic risk factors such as dyslipidemia and obesity may have the major role in developing and progression of NAFLD taking in consideration the limitations of case-control study and the small sized population included.