Association between diabetes and characteristics of hospitalization in patients with acute pancreatitis
Alena Kirzhner, Hefziba Green, Guy Lin, Haitham abu Khadija, Ramon Cohen, Andaleeb Mari, Tal SchillerObjective:
Data on the influence of diabetes and the prognosis of acute pancreatitis (AP) remains limited. We aimed to characterize the clinical course and prognosis of patients hospitalized with a principal diagnosis of AP with and without diabetes.
Methods:
This was a single-center hospital-based observational retrospective cohort study of adult patients admitted to the Department of General Surgery at Kaplan Medical Center with AP between 2017 and 2022. Elaborated data were retrieved from the electronic medical records. The main adverse outcomes included infections, necrotizing pancreatitis, surgery due to these complications, organ failure, intensive care unit admission, in-hospital mortality, length of hospitalization, and three months of all-cause readmission after the index hospitalization.
Results:
350 adult patients with AP were included, of which 101 (29%) had diabetes. Diabetic patients were older and had a higher prevalence of comorbidities. Despite these differences, the presence of diabetes did not correlate with any of the adverse hospitalization outcomes except a three-fold higher risk for re-admissions in the three months post-discharge due to AP complications (9% vs 3%, p=0.025). Using logistic regression, the risk factors significantly associated with unfavorable outcomes among diabetic patients included age, background congestive heart failure (OR 5.064, 95% CI 1.036–24.742,
Conclusion:
Although diabetic patients had less favorable characteristics at baseline most hospitalization outcomes were comparable to patients without diabetes.