Rüdiger von Kries, Frank R. Greer, John W. Suttie

Assessment of Vitamin K Status of the Newborn Infant

  • Gastroenterology
  • Pediatrics, Perinatology and Child Health

SummaryThis article reviews our current knowledge of the assessment of vitamin K status in the human infant, where a deficiency state has been described. Laboratory measures for the functional assessment of vitamin K‐dependent coagulation factors as well as the quantitative assay for vitamin K1 (phylloquinone) are reviewed. In addition, four different methods of measuring abnormal prothrombin, a protein induced by vitamin K absence (PIVKA‐II), and its use in clinical pediatrics are discussed. Finally, additional methods are briefly described for assessing vitamin K status, including serum osteocalcin, urinary excretion of γ‐carboxyglutamic acid, and deficiencies of the enzymes necessary for the regeneration of phylloquinone in the so‐called vitamin K cycle.

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