DOI: 10.4103/jdmimsu.jdmimsu_306_23 ISSN: 0974-3901

Assessment of the Impact of a Multistrain Probiotic on the Quantity of Saliva in Completely Edentulous Patients: An Observational Study

Navdha Gupta, Pankaj Dhawan, Harsimran Kaur, Shivam Singh Tomar, Shakila Mahesh, Piyush Tandan
  • General Medicine



Probiotics are being used to treat oral infections, for instance, periodontitis, caries, fungal infections, and halitosis. Probiotics play a significant role in the overall health of infants, teenagers, adults, and the elderly. However, there is scarce literature regarding its role in completely edentulous patients.


The aim of this study was to assess the impact of multistrain probiotics on the quantity of saliva in completely edentulous patients.

Materials and Methods:

A total of 52 patients were recruited for the study, who were completely edentulous and wearing removable complete denture prostheses. These patients were divided into two groups. Group I (experimental) patients on multistrained probiotics named Lee-Biotic (Leeford Healthcare Ltd.) and Group II (control) consisted of patients who were not prescribed any probiotics. Saliva samples of all the patients were collected at the baseline, after 2 months, and after 3 months. The complete data were formulated systematically on the Microsoft Excel sheet, and then, it was analyzed using the Statistical Package for the Social Sciences version 21.


The mean value of the amount of saliva at the baseline in probiotic and nonprobiotic groups was 2.042 ml and 0.888 ml, respectively (P < 0.001 for both). After 3 months, there was a significant increase in the amount of saliva; i.e. for the probiotic group, it was 2.219 ml, and for nonprobiotic, it was 1.273 ml.


Commercially available multistrain probiotic supplements increased the quantity of saliva in edentulous patients who were old denture wearers.

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