Assessment of the Appropriateness of Drug Prophylaxis for One‐Day Chemotherapy‐Induced Nausea and Vomiting: A Multicenter Study in China
Jiawei Song, Xiaoqian Liu, Jingyu Xu, Long Wang, Jie Fan, Yuanyuan WangObjective
To assess the appropriateness of antiemetic prophylaxis for one‐day chemotherapy‐induced nausea and vomiting (CINV), aiming to provide a reference for optimizing CINV drug prophylaxis practices.
Methods
A multicenter retrospective study was conducted, including a total of 643 cases of CINV prophylaxis from five Grade A tertiary comprehensive hospitals in Anhui Province, China, between January and June 2024. The appropriateness of the instances was comprehensively scored using the attribute hierarchical model (AHM) method, based on established criteria for evaluating the appropriateness of CINV prophylaxis.
Results
The mean score for all cases was 78.65 ± 11.98. Of these, 165 cases (25.66%) scored ≥ 90, 137 cases (21.31%) scored 80 to < 90, 304 cases (47.28%) scored 60 to < 80, and 37 cases (5.75%) scored < 60. The main inappropriateness of prescribing identified was as follows: the prophylactic regimen was not recommended by guidelines (441 cases, 68.58%); the prophylactic regimen was not selected according to the emetogenic risk of chemotherapy drugs (314 cases, 48.83%); the duration of prophylaxis was unreasonable (268 cases, 41.68%); the dosage was inappropriate (178 cases, 27.68%); and the timing of administration was not suitable (156 cases, 24.26%).
Conclusion
The guideline‐recommended one‐day intravenous chemotherapy regimens demonstrate poor adherence, and a considerable number of inappropriate prescribing practices were observed in the prophylactic drug regimens used for one‐day intravenous chemotherapy. The inappropriateness of CINV drug prophylaxis is relatively concentrated, and targeted interventions are needed to improve the appropriateness of CINV prophylaxis prescribing.