DOI: 10.4103/mjbl.mjbl_166_24 ISSN: 1812-156X

Assessment of Some Iron Metabolism Biomarkers in Patients with Ischemic Heart Disease

Hanna Abdulkareem Hussein, Maysaa Adil Hadi, Walaa Salih Hassan
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Abstract

Background:

Ischemic heart disease (IHD) is the most common form of cardiovascular disease.

Objectives:

This study aimed to assess changes in iron metabolism and red blood cell (RBC) biomarkers in patients with IHD.

Materials and Methods:

This case–control study comprised 70 IHD patients and 30 healthy individuals. All participants’ ages ranged from 40 to ≥70 years and were divided into four age groups: 40–49, 50–59, 60–69, and ≥70 years. The serum concentrations of ferritin, total iron, transferrin, hepcidin (HCN), soluble transferrin receptor, and myeloperoxidase were measured using the enzyme-linked immunosorbent assay technique. In addition, RBC biomarkers were estimated.

Results:

A significant difference ( P ≤ 0.05) was found between the age groups. The age group ≥70 years was the most frequent, followed by 50–59 years, 60–69 years, and 40–49 years. Moreover, males were more frequent than females, with no significant differences. According to family history, smoking status, and coronavirus status, a significant difference was found between the age groups. Moreover, a significant increase ( P ≤ 0.0001) in IHD patients with hypertension and diabetes. The concentration of total iron, soluble transferrin receptors, and transferrin was found to be significantly decreased ( P ≤ 0.0001 and ≤0.007), respectively, whereas a significant increase ( P ≤ 0.0001) in ferritin and HCN in IHD patients compared with the control. There was a significant decrease ( P ≤ 0.05) in RBC count, hemoglobin, and hematocrit, while significant increase ( P ≤ 0.05) in mean corpuscular volume and mean corpuscular hemoglobin concentration. Many significant correlations between iron metabolism and RBC biomarkers were recorded.

Conclusion:

The serum iron metabolism biomarkers were significantly affected and had many significant correlations with RBC biomarkers in patients with IHD.

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