Assessment of Some Immunological Parameters Among Ischemic Heart Disease in Iraqi Patients
Zainab Mohammed Almadany, Afaf K. ShwaikhAbstract
Background:
Ischemic heart disease (IHD) presents a significant burden on individuals and healthcare systems globally. The prevalence of risk factors, along with an aging population, continues its status as the leading cause of death worldwide. Immunological mediators play a clear role in the development of heart disease, as some studies have indicated their importance in the pathogenesis of IHD.
Objectives:
This article aimed to evaluate the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and the changes in IL-6 receptor in IHD patients.
Materials and Methods:
A total of 90 samples, including 60 from IHD patients aged 40–85 years, and 30 randomly selected controls with matching age range. Serum levels of TNF-α, IL-6, and human soluble IL-6 receptor (sIL-6R) were measured using the enzyme-linked immunosorbent assay method, which was estimated according to the manual procedure of Bioassay Technology Laboratory kit from China.
Results:
In the IHD group, IL-6 and sIL-6R levels were markedly elevated compared to control subjects. In addition, TNF-α showed a significant increase (
Conclusion:
Increased concentrations of IL-6, sIL-6R, and TNF-α might have a crucial contribution to coronary endothelial dysfunction in IHD patients.