Assessment of Osteopontin and KIM-1, as Diabetic Nephropathy Markers in Type 2 Diabetes Mellitus Patients in Babylon City
Mohmmed Jero Zrage, Murtadha M. JawadAbstract
Background:
Diabetic nephropathy (DN) is one of the most severe long-term effects of diabetes mellitus (DM). Diabetes is the most common cause of end-stage renal disease in many different nations.
Objectives:
To assess the levels of osteopontin and KIM-1 in patients with DN and to identify the risk factors associated with DN.
Materials and Methods:
This study included ages above 18 years old. This study included a convenience sampling of 135 individuals. The study comprised three groups: 45 patients with nephropathy (macroalbuminuria) and DM, 45 patients with only DM, and 45 individuals in the control group. Osteopontin (OPN) and kidney injury molecule-1 (KIM-1) were estimated by enzyme linked immunosorbent assay (ELISA) kit. The study was conducted in Marjan Medical City and Imam Sadiq Teaching Hospital in Babylon governorate from September 2023 to April 2024.
Results:
The current study reveals that the patients with DN have significantly higher OPN and KIM-1 levels compared to those with DM only and the control group (
Conclusion:
The study indicated that DN patients had greater OPN and KIM-1 levels compared to other groups. The research also found a significant association between OPN, KIM-1, and duration of diabetes.